Influences of repetitive transcranial magnetic stimulation combined with brain fluctuation map therapy on cognitive function and neurotransmitter levels in patients with depression
Objective To explore the characteristics of brain fluctuation map in detecting the changes of neuro-transmitter power after repetitive transcranial magnetic stimulation(RTMS)in patients with depression.Methods From June 2021 to November 2022,200 patients with depression who were treated in Shijiazhuang Eighth Hospital were taken as the research objects and randomly grouped into two groups.All patients underwent brain fluctuation map exami-nation.The patients in the control group were treated with venlafaxine,and the patients in the treatment group were trea-ted with repetitive transcranial magnetic stimulation based on control group.After treatment,all patients were examined by brain fluctuation map again,and the cognitive function and neurotransmitter levels were compared between the two groups after treatment.Results The total effective rate of the treatment group was 92.00％,which was higher than that of the control group(75.00％),the difference was statistically significant(P＜0.05).After 2 weeks and 6 weeks of treatment,the scores of Hamilton Depression Scale in the treatment group were 15.88±3.96 and 12.74±3.51,which were lower than those in the control group(19.72±4.67 and 16.65±4.12),and the differences were statistically sig-nificant(P＜0.05).After 6 weeks of treatment,the number of false responses in the treatment group was lower than that in the control group(P＜0.001),but the number of correct responses,the number of completed classification and the number of total responses were higher than that in the control group(P＜0.001).Six weeks after treatment,the power values of norepinephrine and dopamine in the treatment group were 198.63±38.57 and 115.27±12.71,which were higher than those in the control group(175.67±34.86 and 101.23±12.46),the difference was statistically significant(P＜0.05).Conclusions Repetitive transcranial magnetic stimulation can improve the cognitive function of patients with depression and effectively regulate the level of neurotransmitters.
Depressive disorderTranscranial magnetic stimulationcognitionNeurotransmitterBrain fluctua-tion map
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