Objective To investigate the clinical characteristics,treatment and prognosis of prostate cancer in elderly patients aged 80 years or older in our hospital.Methods Retrospective collection of clinical data from 52 pa-tients aged ≥80 years with prostate cancer admitted to the First Affiliated Hospital of University of Science and Technol-ogy of China from October 2020 to November 2022,including age,total prostate-specific antigen(tPSA),biopsy Gleason scores,clinical stage,initial treatment,survival and other outcomes.Results For all the 52 patients,the average age was(82.9±2.6)years old,57.7％had Gleason scores ≥8,71.2％had stage Ⅲ-Ⅳ,and 28.8％had metastasis.In pa-tients with non-metastatic prostate cancer,15 patients underwent radical prostatectomy and 22 received endocrine thera-py.15 men with metastatic prostate cancer received endocrine therapy,and two of them combined with radiotherapy.Dur-ing the follow-up of 12 to 41 months,no serious complications occurred in patients who underwent radical surgery,and mild urinary incontinence occurred in 1 case,biochemical recurrence occurred in 3 cases,no death was reported.The KPS functional status score of patients who underwent radical surgery[90(70,90)points]was significantly higher than that of patients who underwent non-radical surgery[75(60,80)points],and the difference was statistically significant(P＜0.05).There were 8 cases progressed and 5 died in the patients with metastatic prostate cancer.Conclusions Elderly patients with prostate cancer have higher Gleason scores,later clinical stages,and poorer prognosis,who need ac-tive curative treatment.For non-metastatic elderly patients with prostate cancer with good condition,radical prostatectomy is a safe,effective treatment option,which might maintain and improve the functional status.
Prostatic neoplasmsProstatectomyDisease attributesPrognosisAged,80 and over
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