摘要
失眠与焦虑之间存在着一种相对独立,却又相互作用的关系.焦虑会导致失眠反复发作,反之失眠也可加重焦虑状态,两者在临床常以共病形式存在.该文通过系统梳理文献,发现失眠共病焦虑的机制比较复杂,最主要涉及5-羟色胺系统、下丘脑-垂体-肾上腺轴、食欲素及其受体通路、多巴胺通路、神经活性配体-受体相互作用通路等神经生物学通路.
Abstract
Insomnia and anxiety have a relatively independent but interactive relationship.Insomnia can cause the aggravation of anxiety,and anxiety can also cause recurrent attacks of insomnia.In the form of comorbidity,the two frequently coexist.By systematically reviewing the literature,we found that the mechanism of insomnia combined with anxiety is complex,but the most important ones are 5-hydroxytryptamine system,hypothalamic pituitary adrenal axis,Orexin and its receptor pathway,dopamine,Neuroactive Ligand-Receptor Interaction Signaling Pathway,and other neuro-biological pathways.
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