Obesity is a chronic metabolic disease,and the prevalence rate is increasing year by year.Obesity is an important risk factor for chronic diseases such as cardio cerebrovascular diseases,diabetes and various cancers,which has brought a huge burden to patients'physical and mental health as well as the country's medical care.Now there are a variety of weight loss methods and drugs,with different effects and drawbacks.This article briefly reviews the research pro-gress of existing weight loss methods and drugs in order to provide a certain reference for the more reasonable application of weight loss methods and drugs,and to provide a certain reference for the research and development of weight loss drugs.