Anti-melanoma differentiation-associated gene 5(MDA5)antibody-positive dermatomyositis is a subtype of DM characterized by a high propensity for developing interstitial lung disease,particularly rapidly progres-sive ILD(RPILD).Patients with RPILD often exhibit resistance to corticosteroid and immunosuppressive treatments,resulting in a high mortality rate of 70％despite active intervention,posing a serious threat to patient survival.There-fore,heightened attention to this condition is warranted.This article reviews the pathogenesis,clinical characteristics,and treatment advancements of anti-MDA5 positive dermatomyositis,with a particular emphasis on early identification and warning methods for RPILD in these patients.
关键词
皮肌炎/体征和症状/抗黑色素瘤分化相关基因5/临床方案
Key words
Dermatomyositis/Signs and symptoms/anti-MDA5/Clinical protocols
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