Expression of serum phosphorylated tau protein 181 and Kallikrein 6 in elderly patients with acute cerebral infarction and its predictive value for sleep disorder after illness
Objective To observe the changes of serum phosphorylated tau protein 181(P-tau-181)and Kallikrein 6(KLK6)levels in elderly patients with acute cerebral infarction,and explore the relationship between their levels and sleep disorder after illness.Methods From May 2020 to May 2022,158 elderly patients with a-cute cerebral infarction accepted by Hai'an People's Hospital were gathered as observation subjects,according to the National Institutes of Health Stroke Scale(NIHSS)score,they were grouped into mild group(40 cases),mod-erate group(81 cases),and severe group(37 cases);after treatment,the patients were separated into sleep disor-der group(56 cases)and good sleep group(102 cases)according to the Pittsburgh Sleep Quality Index(PSQI)score;the levels of P-tau-181 and KLK6 in the serum were detected using enzyme-linked immunosorbent assay;Lo-gistic regression analysis was applied to analyze the influencing factors of sleep disorder in elderly patients with a-cute cerebral infarction after treatment;receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum P-tau-181 and KLK6 levels for sleep disorder in elderly patients with acute cerebral in-farction after treatment.Results The serum levels of P-tau-181 and KLK6 of acute cerebral infarction patients in the severe group were obviously higher than those in the mild and moderate groups(P＜0.05),while the serum levels of P-tau-181 and KLK6 in the moderate group were obviously higher than those in the mild group(P＜0.05).Compared with the patients in the good sleep group,the proportions of family history of stroke,smoking his-tory and drinking history,and the serum levels of P-tau-181 and KLK6 in the sleep disorder group were obviously higher(P＜0.05).Serum levels of P-tau-181 and KLK6 were independent risk factors for sleep disorder in elderly patients with acute cerebral infarction after treatment(P＜0.05).The area under the receiver operating character-istic of serum P-tau-181,KLK6 and their combination in diagnosis of sleep disorder in elderly patients with acute cerebral infarction after illness was 0.844,0.826 and 0.924,respectively,the combined diagnostic efficacy was higher than those of the individual detection efficacy(Z=2.030,P=0.042;Z=2.340,P=0.019).Conclu-sions The high expression of P-tau-181 and KLK6 in the serum of elderly patients with acute cerebral infarction may have an important relationship with sleep disorder after illness,and both of them are more effective than one of both for sleep disorder after illness in elderly patients with acute cerebral infarction.
Brain infarctiontau ProteinsKallikreinsSleep wake disordersAged
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