With the continuous development of tumor immunotherapy,immune checkpoint inhibitor-associated diabetes mellitus is gradually increasing,mainly with acute complications of diabetes mellitus.For example,diabetic ke-toacidosis is the first symptom of the emergence of the patient's rapid disease progression,and the condition of the pa-tient is critical.For clinicians,early identification,diagnosis,and treatment are particularly important,and at the same time,it is also important to identify patients who are prone to acute complications of diabetes after the use of immune checkpoint inhibitors.This review outlines the clinical features,epidemiology,pathomechanisms,diagnostic and treatment methods,and management of immune checkpoint inhibitor-associated diabetes mellitus,with the hope of assisting clini-cians and increasing their awareness and vigilance of immune checkpoint inhibitor-associated diabetes mellitus.