Aprocitentan(Tryvio)is an oral medication and an administered dual endothelin A/endothelin B(ETA/ETB)receptor antagonist.It is approved by the U.S.Food and Drug administration(FDA)on March 19,2024.It is used in combination with other antihypertensive drugs,to lower blood pressure in adult patients who are not adequately controlled on other traditional drugs.Through a comprehensive review of the mechanism of action,pharmacokinetics,clin-ical trials,adverse effects,considerations for specific patient populations,and precautions regarding aprocitentan,this aims to provide clinical physicians with new strategies for the treatment of resistant hypertension(RH).
关键词
抗高血压药/内皮素受体拮抗剂/高血压,难治性/药理学和毒理学现象
Key words
Antihypertensive agents/Endothelin receptor antagonists/Hypertension,treatment-resistant/Phar-macological and toxicological phenomena
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