Objective To evaluate the clinical value of peripheral perfusion index(PPI)in predicting fluid re-sponsiveness in patients with sepsis.Methods A total of 65 patients with sepsis admitted to Lixin County People's Hos-pital between April 2021 and July 2024 were selected for the study.Following a confirmed diagnosis of sepsis,a fluid challenge test was immediately conducted to assess the patients'fluid responsiveness.The fluid challenge method in-volved rapid infusion of 200 mL crystalloid solution within one minute.If the velocity time integral(VTI)increased by 10％after fluid infusion,the patient was considered fluid-responsive.Subsequently,an additional 300 mL of crystalloid solution was infused over 15 minutes to further verify fluid responsiveness.Results Thirty-six patients responded to the fluid challenge test.After the rapid infusion of 200 mL crystalloid,the critical ΔPPI value for predicting fluid responsive-ness was 10.99％(AUC=0.99,sensitivity=100％,specificity=94.4％).After the additional infusion of 300 mL flu-id,the critical ΔPPI value for predicting fluid responsiveness was 16.67％(AUC=0.97,sensitivity=82.7％,specificity=100％).There was no statistically significant difference in the area under the curve(P=0.118)between two groups.Conclusion During fluid therapy in septic patients,PPI demonstrates good clinical value in predicting fluid responsive-ness.
维普
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