Objective To explore the relationship between hyperuricemia(HUA)and the development of frail-ty in elderly patients with obstructive sleep apnea(OSA).Methods A total of 716 elderly male patients diagnosed with OSA were collected from 6 sleep centers in Beijing and Gansu from January 2015 to October 2017.Based on the levels of uric acid in the patients,83 patients with high uric acid were selected and defined as the high uric acid group.After matching for age,body mass index,apnea-hypopnea index(AHI),and alcohol consumption,83 patients with nor-mal uric acid levels were selected and defined as the normal uric acid group.Cox survival analysis was used to explore the relationship between hyperuricemia and frailty.Results Compared with the normal uric acid group,the high uric acid group had a higher frailty score,triglycerides and and a higher incidence of hypertension,renal insufficiency,and frailty,and a lower mean pulse oxygen saturation,with statistically significant differences(P＜0.05).Multivariate Cox analysis showed that HUA(aHR=2.626,95％CI:1.405-4.909;P=0.002)was an independent risk factor for frailty in elderly male OSA patients.Spearman correlation analysis showed that uric acid was significantly correlated with frailty(r=0.198,P=0.011)and frailty score(r=0.337,P＜0.001).Subgroup analysis showed that patients less than 80 years old(aHR=4.992,95％CI:1.988-12.533;P=0.001)and patients with AHI ≥30(aHR=4.384,95％CI:1.501～15.474;P=0.008)had a higher risk of frailty when combined with HUA.Conclusions HUA is an independ-ent risk factor for frailty in elderly male OSA patients.When merging HUA,elderly patients under 80 years old or with severe OSA have a higher risk of frailty.
维普
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