首页|食源性抗氧化剂缓解内分泌干扰物生殖毒性的研究进展

食源性抗氧化剂缓解内分泌干扰物生殖毒性的研究进展

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  • 国家科技期刊平台
  • NETL
  • NSTL
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内分泌干扰物(EDCs)是一类广泛存在于日常生活环境中的化学物质,可通过多种途径进入人体,危害生殖发育和健康.氧化应激(OS)是EDCs产生生殖毒性的重要基础机制之一.大量研究发现,EDCs暴露通过增加人体生殖系统的活性氧(ROS)水平,同时降低酶促抗氧化剂的活性和数量,进而导致氧化应激,从DNA和细胞等各个层面诱导生殖系统的损伤.许多研究结果表明,补充食源性非酶促抗氧化剂能够清除人体内的ROS,并增加酶促抗氧化剂的活性,从而降低OS水平,并进一步修复EDCs诱导的生殖损害.另外,许多食源性抗氧化剂本身也是参与生殖生理活动的重要元素,对生殖健康具有保护作用.本文归纳了EDCs的生殖毒性,包括损伤生殖细胞、干扰性激素作用和影响生殖相关基因的表观遗传调控,阐述了OS在EDCs诱导生殖毒性中的作用,进一步总结了多种维生素、微量元素以及植物中的多酚和色素等食源性抗氧化剂缓解EDCs生殖毒性的作用及相关机制,为防治EDCs的生殖毒性提供理论基础和科学依据.
Research progress on food-derived antioxidants for alleviating toxicity of endocrine disrupting chemicals
Endocrine disrupting chemicals(EDCs)are a class of chemical substances widely present in daily-life environment,and can enter human body through various pathways,posing a threat to reproductive development and health.Oxidative stress(OS)is one of the most important funda-mental mechanisms underlying the reproductive toxicity of EDCs.Numerous studies have found that exposure to EDCs can increase the levels of reactive oxygen species(ROS)in human repro-ductive system and reduce the activity and quantity of multiple enzymatic antioxidants,leading to oxidative stress and inducing damage to the reproductive system at various levels such as DNA and cells.Many research results have shown that supplementing food-derived non-enzymatic antioxidants can reduce ROS levels and increase the activity of enzymatic antioxidants,thereby reduce OS levels,and further repair EDCs-induced reproductive damage.In addition,many food-derived antioxidants are important elements involved in reproductive physiological activities and have protective effects on reproductive health.This paper summarized the reproductive toxicity of EDCs,including damage to reproductive cells,interference with hormone action,and influence on reproductive-related epigenetic regulation,elaborated the relationship between OS and re-productive toxicity of EDCs,and further summarized the alleviating effects and related mecha-nisms of food-derived antioxidants such as vitamins,trace elements,and plant polyphenols and pigments against reproductive toxicity of EDCs,aiming to provide a theoretical and scientific basis for prevention and treatment against reproductive toxicity of EDCs.

endocrine disrupting chemicalfood-derived antioxidantreproductive toxicityoxida-tive stressepigenetic regulation

陈佳娴、苗茂华、王子亮

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复旦大学公共卫生学院,上海 200032

上海市生物医药技术研究院,公共卫生与政策研究所/国家卫生健康委员会计划生育药具重点实验室/上海市疾病与健康基因组学重点实验室,上海 200237

内分泌干扰物 食源性抗氧化剂 生殖毒性 氧化应激 表观遗传调控

国家自然科学基金项目上海市自然科学基金项目上海市生物医药技术研究院省部级重点实验室创新能力专项资助项目

8190334623ZR1457100RC2023-03

2024

10.11836/JEOM23250

环境与职业医学
上海市疾病预防控制中心 中华预防医学会

环境与职业医学

CSTPCD北大核心
影响因子：0.71
ISSN：1006-3617
年,卷(期)：2024.41(1)
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