Difference of clinical characteristics and prognosis of COVID-19 complicated with or without pneumoconiosis in hospitalized patients
[Background]The novel coronavirus infection is widespread in the world,resulting in more pneumoconiosis patients complicated with coronavirus disease 2019(COVID-19).[Objective]To understand the clinical characteristics and prognosis of hospitalized COVID-19 pa-tients complicated with or without pneumoconiosis.[Methods]A total of 36 COVID-19 patients admitted to the Shandong Provincial Occupational Disease Hospital from 10 December to 31 December 2022 were selected,including 21 cases in the complication group(pneumoconiosis complicated with COVID-19)and 15 cases in the COVID-19 group without pneumoconiosis.Symptoms,signs,laboratory test results(e.g.routine blood test),imaging findings,treatment plans and prognosis of the two groups were observed and compared.[Results]Regarding symptoms and signs in the complication group and the COVID-19 group,the proportions of dyspnea(57.14%vs 0.00%),lung wheezing(28.57%vs 0.00%),wet rales(76.19%vs 33.30%),and fever(61.90%vs 93.33%)were significantly different(P<0.05).Compared with the COVID-19 group,the level of D-dimer in the complication group was significantly increased[2.340(1.0,6.5)mg·L-1 vs 0.250(0.2,0.4)mg·L-1](P<0.01),the serum sodium level was decreased[(138.10±2.68)mmol·L-1 vs(140.47±2.27)mmol·L-1](P<0.05).In terms of drug treatment and prognosis,there were statistically significant differences in the proportion of antiviral drugs(19.00%vs 80.00%),glucocorticoids(38.10%vs 80.00%),and anticoagulants(28.60%vs 0.00%)between the complication group and the COVID-19 group(P<0.05).Compared with the COVID-19 group,the cure rate of the complication group(90.50%vs 100.00%)showed no statistical difference.However,there were 2 deaths in the complication group.[Conclusion]Patients with pneumoconiosis complicated with COVID-19 have less fever and more dyspnea,wheezing,and wet rales.The increase of plasma D-dimer is a potential predictor in patients with pneumoconiosis complicated with COVID-19.
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