The Independent Association of Free Triiodothyronine Levels with Lymphocyte Counts Among COVID-19 Patients in Intensive Care Unit
Objective To study the correlation between thyroid function and lymphocyte counts in patients infected with COVID-19 in intensive care unit.Methods:A retrospective analysis was conducted on the clinical and laboratory data of 122 patients infected with COVID-19 who were admitted to the Intensive Care Unit of Sun Yat-sen Memorial Hos-pital from November 08,2022,to May 31,2023.The endpoint of observation was discharge or death.The patients who died in hospital or signed to abandon treatment were considered as poor prognosis,the other were good prognosis.The clinical data and laboratory examination of the two groups were analyzed.Meanwhile,the thyroid function and lympho-cyte counts were compared to analyze the correlation.Finally,binary logistics regression analysis was used to predict the probability of patients getting poor prognosis to fit the model,and the risk factors independently affecting the prognosis were obtained.Results:White blood cell count(WBC),neutrophil counts and APACHE Ⅱ score,SOFA score,total bilirubin(TBIL),creatinine(Cr),,glucose(GLU),D-Dimer(D-Dimer),quantitative determination of procalcitonin(PCT),and ratio of neutrophil count to lymphocyte count(NLR)were significantly higher than those of patients with good prognosis.Albumin(ALB)concentration,lymphocyte count,free triiodothyronine(FT3)concentration and thyro-tropin(TSH)concentration were all lower than those in the good prognosis group.FT3 level in thyroid function was inde-pendently correlated with lymphocyte count,an indicator of immune function.NLR,SOFA score and APACHE Ⅱ score were independent risk factors for poor prognosis,and the accuracy of the prediction model was 86.1%.Conclusion:FT3 levels were positively correlated with lymphocyte count in patients with COVID-19 in intensive care unit.The increase of NLR is associated with poor prognosis of patients and is an independent risk factor for poor prognosis of COVID-19 pa-tients in intensive care units.
intensive care unitnovel coronavirus infectionthyroid functionneutrophil/lymphocyte ratio
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