宏基因组第二代测序技术在狂犬病诊断中的应用
Application ofRabies Diagnosisby Metagenomic Next-Generation Sequencing Technology
汪绪伦 1刘菲菲 2朱成楼 1周志森 1陈锦江 1刘涛 1郭晓磊2
作者信息
- 1. 广东省东莞市横沥医院(523460)
- 2. 广东省广州金域医学检验中心
- 折叠
摘要
目的:总结宏基因组第二代测序技术(mNGS)诊断狂犬病临床应用价值.方法:回顾性分析广东省东莞市横沥医院1例和文献报告3例狂犬病诊疗资料.结果:4例患者唾液或脑脊液标本的mNGS检测狂犬病毒结果均为阳性,其中3例患者同时进行了狂犬病毒PCR检测亦为阳性.结论:唾液和脑脊液标本行mNGS检测为临床确诊狂犬病提供依据.
Abstract
Objective:To summarize the clinical application of metagenomic next-generation sequencing(mNGS)in the diagnosis of rabies.Methods:The diagnosis and treatmentdataof1caseof rabies in our hospital and 3 cases of litera-ture searchwere retrospectively.Results:4 patients were tested positive for rabies virus by mNGS.3 patients were tested positive by PCR at the same time,providing a basis for clinical diagnosis of rabies.Conclusion:Itprovedaclinicaldiag-nosticbasisofrabiesdetected samplesofsalivary and cerebrospinal fluid by mNGS.
关键词
狂犬病/宏基因组第二代测序技术/诊断Key words
rabies/metagenomic next-generation sequencing technology/diagnosis引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据