The Value of Combined Detection of miR-21 and NF-κB in Evaluating the Risk of Recurrence in Patients with Papillary Thyroid Carcinoma
Objective:To investigate the value of combined detection of miR-21 and NF-κB in evaluating the recurrence risk of PTC patients.Methods:80 patients with papillary thyroid carcinoma admitted to the Third People's Hospital of Shunde District,Foshan City,Guangdong Province from Jan 2021 to Oct 2022 were included in the study.According to the recurrence situation of patients 1 year after discharge,they were divided into a recurrence group(n= 23)and a non-recurrence group(n=57).Multivariate Logistic regression was used to analyze the correlation between serum miR-21 and NF-κB and the risk of relapse in PTC patients,and ROC curve was drawn to evaluate the predictive value of combined detection of Mir-21 and NF-κB on the risk of relapse in PTC patients.Results:There were significant differences in miR-21 and NF-κB levels in age,pathological stage,tumor size and cervical lymph node metastasis between the two groups(P<0.05).Multivariate analysis showed that age>55 years,lymph node metastasis,miR-21 and NF-κB expression were independent risk factors for relapse in PTC patients.ROC curves show that miR-21,the nf-kappa B and the joint detection area under the curve is 0.895,0.895 and 0.960.Conclusion:The up-regulation of miR-21 and NF-κB levels is associated with the risk of postoperative recurrence in PTC patients,and the combined detection has higher predictive value,and can be used as an effective index to assist clinical evaluation of postoperative recurrence risk in PTC patients.
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