Effects of Early Enteral Nutrition Intervention on Immune Balance and Prognosis of Patients with Septic Shock
Objective:To summarize the effects of early enteral nutrition(EEN)intervention on immune balance and prognosis of patients with septic shock.Methods:A total of 82 patients with septic shock admitted to Jiyuan People's Hospital were enrolled from Oct 2018 to Oct 2023.According to different EN intervention methods,they were divided into EEN group(n=39,EN intervention within 24 h after admission)and DEN group(n=43,EN intervention within 48h after admission).The changes of serum nutritional indexes,immune balance indexes and inflammatory factors before and after intervention,and adverse reactions during intervention,the stay time in ICU,scores of acute physiologi-cal and chronic health Ⅱ(APACHE Ⅱ)and sequential organ failure assessment(SOFA)before and after intervention were compared between the two groups.Results:Compared with DEN group after 7 d of intervention,levels of serum to-tal protein(TP),albumin(Alb)and prealbumin(PAB)were significantly higher in EEN group,while Treg/Th17,lev-els of serum C-reactive protein(CRP)and interleukin(IL)-6,scores of APACHE Ⅱand SOFA were significantly lower(P<0.05).The incidence of metabolic disorders in EEN group was significantly lower than that in DEN group,and stay time in ICU was significantly shorter than that in DEN group(P<0.05).Conclusion:EN intervention can effectively im-prove nutritional status and immune balance in patients with septic shock,and EEN is more effective,which may have positive impact on disease recovery.
万方数据
维普
