Objective:To explore the value of ischemic conditioning and application in the treatment of direct PCI inpatients with AMI.Methods:100 patients with acute ST-segment elevation myocardial infarction(STEMI)admitted to the hospital from Jul 2019 to Dec 2022 were randomly divided into control group(n=48)and study group(n=52),re-ceived direct PCI treatment and combined ischemic postconditioning therapy and the alprostadil treatment.The incidence of slow blood flow/no reflow during surgery,postoperative inflammatory markers,renal function,cardiac function,myocar-dial enzyme peaks,ST-segment regression on electrocardiograms and adverse cardiovascular events were compared be-tween the tow groups.Results:Postoperative MHR,NLR BUN,Cr,and eGFR in the study group were significantly better than those in the control group(all P<0.05).At the 6-month follow-up,the LVEF of both groups had significantly in-creased compared to the postoperative measurements.The LVEF in the study group was better than that in the control group(P<0.05).The incidence of slow blood flow/no reflow during surgery in the study group was lower than that in the control group(P<0.05).The proportion of ST segment regression≥50%in the study group 2 hours after surgery was sig-nificantly better than that in the control group(P<0.05).At the 6-month follow-up,there was significant difference in the incidence of heart failure and angina pectoris between the two group(P<0.05).Conclusion:Undergoing PCI combining ischemic postconditioning with alprostadil effectively reduces postoperative inflammatory reaction,restores myocardial re-perfusion,enhances cardiac and renal function,and ultimately improving prognosis for patients with STEMI.
关键词
缺血后适应/前列地尔/急性心肌梗死/ST段抬高/经皮冠状动脉介入/心功能/肾功能
Key words
ischemic postconditioning/alprostadil/acute myocardial infarction/ST segment elevation/percuta-neous coronary intervention/cardiac function/renal function
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