Objective:To investigate the clinical significance of dynamic monitoring of CRP(C-reactive protein)and PTX3(penetran-3)levels in the treatment of severe pneumonia by bronchoalveolar lavage.Methods:From August 2022 to August 2023,160 patients with severe pneumonia in our hospital were selected as the study objects.According to the patients'condition,they were divided into the improvement group and the deterioration group.On the first,fourth and seventh day of the course of the selected patients,peripheral venous blood was drawn,and cytokines and bronchoal-veolar lavage fluid were measured.The serum levels of CRP and PTX3 were detected by enzyme-linked immunosorbent assay(ELISA),and the effects of the changes of the two levels on the disease were analyzed.Results:The levels of CRP and PTX3 in blood and bronchoalveolar lavage fluid in the improvement group and the deterioration group showed a downward trend with the improvement of the patient's condition.The levels of CRP and PTX3 in blood and bronchoalveo-lar lavage fluid in the deterioration group were higher than those in the improvement group(P<0.05);The levels of CRP and PTX3 were negatively correlated with the severity of the disease(P<0.05).With the increasing levels of CRP and PTX3,the condition of elderly patients with severe pneumonia worsened.Conclusion:The levels of CRP and PTX3 in blood and BALF can reflect the degree of pulmonary infection and the prognosis of patients with severe pneumonia.
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