The Value of S100β in Prognostic Assessment of Patients with Severe Pneumonia
Objective:To explore the value of S100β in assessing the prognosis of patients with severe pneumonia.Methods:With hospital discharge as the study's primary endpoint,we conducted a retrospective analysis of data on 107 patients with severe pneumonia admitted to the emergency department of the First Affiliated Hospital of Sun Yat-sen Uni-versity from May 2021 to October 2023.Patients were categorized into S100β-negative and S100β-positive groups based on their serum S100β levels,and into survival and non-survival groups based on their discharge outcomes.The Glasgow Coma Scale(GCS)score was used to evaluate the level of consciousness on admission,and the CURB-65 score,Se-quential Organ Failure Assessment(SOFA)score,Acute Physiology and Chronic Health Evaluation(APACHE)II score,and the Pneumonia Severity Index(PSI)were used to assess the severity of the patients'conditions.The progno-sis of patients with severe pneumonia was evaluated based on survival status at discharge,duration of mechanical ventila-tion(days),dose of norepinephrine(mg),and duration of continuous renal replacement therapy(CRRT)(days).Re-sults:Among the 107 patients with severe pneumonia,there were 48(44.9％)in the S100β-positive group and 59(55.1％)in the S100β-negative group.Patients in the S100β-positive group had lower Glasgow Coma Scale(GCS)scores and higher Sequential Organ Failure Assessment(SOFA)scores compared to those in the S100β-negative group.The duration of mechanical ventilation,the dose of norepinephrine used,and the length of continuous renal replacement therapy(CRRT)treatment during hospitalization were all higher in the S100β-positive group than in the S100β-negative group.The in-hospital mortality rate in the S100β-positive group(62.5％)was significantly higher than that in the S100β-negative group(23.7％).The combination of S100β with SOFA score and APACHE II score in predicting the prognosis of severe pneumonia can complement the existing scores and improve the specificity of diagnosis.Conclusion:The inci-dence of brain injury in patients with severe pneumonia is relatively high,reaching 44.9％.S100β can reflect the sever-ity of the disease in patients with severe pneumonia and serves as an independent risk factor for predicting an unfavorable prognosis in patients with severe pneumonia.
万方数据
维普
