Analysis of Clinical Characteristics of 61 Cases of Insulinoma
Objective:To summarize the clinical characteristics and experience in the qualitative and localization diagnosis of insulinoma.Methods:A retrospective analysis was conducted on the clinical materials of 61 insulinoma pa-tients confirmed by pathology from 1992 to 2019 at Sun Yat-sen Memorial Hospital.Results:34.4％of the patients were misdiagnosed,with 70.5％of patients exhibiting the typical Whipple's triad.when blood glucose<3 mmol/L,C-pep-tide≥200 pmol/L,insulin≥3 mU/L,Insulin release index(IRI)≥0.3 and amended IRI≥50 occurred in 100％,97.1％,91.2％and 94.1％,respectively.The positive rates of examinations for localization before operation were transabdominal ultrasound 46.3％,CT 82.4％,MRI 86.8％and endoscopic ultrasonography 96.3％.Conclusions:The clinical presenta-tion of insulinoma is complex and diverse,leading to frequent misdiagnosis and missed diagnosis.When blood glucose<3 mmol/L,C-peptide≥200 pmol/L and insulin≥3.0 mU/L should be prioritized as qualitative diagnostic criteria for in-sulinoma.MRI can be considered the primary choice for non-invasive localization examinations,and endoscopic ultra-sound can further improve the detection rate of insulinoma.
万方数据
维普
