The association between chronic low-grade systemic inflammation and ultrasound malignant risk stratification of thyroid nodules
Objective:To explore the relationship between chronic low-grade systemic inflammation and ultrasound malignant risk stratification of thyroid nodules.Methods:The research subjects were 1189 patients with thyroid nodules who participated in the thyroid disorders survey conducted in Guangzhou community in 2015.Information on sociodemographic characteristics and life style was collected using the questionnaires.The thyroid gland was examinated using ultrasound,and the thyroid nodules were classified based on the ACR TI-RADS.Blood samples were collected for the detection of high sensitive C-reactive protein(hs-CRP).The subjects were classified into 3 groups based on the hs-CRP tertile levels,and the prevalence of the different TI-RADS categories of thyroid nodules was analyzed among the 3 groups.Linear stepwise regression analysis was used to examine the relationship between hs-CRP and the TI-RADS categories of thyroid nodules.Results:Compared to the subjects in the low hs-CRP group,the subjects in the high hs-CRP group had higher prevalence of TI-RADS 4 and 5 category thyroid nodules(2.5％vs 24.9％,P<0.05).Linear stepwise regression analysis showed that hs-CRP levels were associated with the TI-RADS categories of thyroid nodules,even after adjustment for age,sex,smoking,drinking,body mass index,and the numbers and size of thyroid nodules(B:0.834,P<0.001).Conclusion:The chronic low-grade systemic inflammation is associated with the ultrasound malignant risk stratification of thyroid nodules.
万方数据
维普
