The effect of liquiritigenin on serum inflammatory factors in rats with hind limb ischemia-reperfusion injury
Objective:Compare the effects of pretreatment with liquiritigenin on serum inflammatory factors in rats during lower limb ischemia-reperfusion injury.Methods:Twenty-four rats were randomly divided into three groups(n=8).Group I was the normal control group;Group II was the model group;III received intravenous injection of 50 mg/L licorice liquid before the model was established.After 24 hours of perfusion,the morph changes in the gastrocnemius muscle tissue of the rats were observed under a microscope,and the contents of TNF-α,IL-6,CK the rat serum and the activity of SOD were determined by ELISA.Results:Compared with the control group,the serum TNF-α and IL-6 levels,and CK content increased,and the SOD activity 24 hours after reperfusion(P<0.05);compared with the ischemia group,the serum TNF-α and IL6 levels,and CK content decreased,and the SOD activity increased24 hours after reperfusion in theiquiritigenin treatment group(P<0.05),and the pathological damage of the gastrocnemius muscle tissue was alleviated 24 hours after reperfusion.Conclusion:Liquiritigenin pretreatment can alleviate the inflammatory response and oxidative stress response in rat lower limb ischemia-reperfusion.
万方数据
维普
