摘要
目的:分析我院腹腔感染病原菌分布及耐药情况,指导临床合理用药.方法:统计我院2018年9月到2024年7月腹腔感染相关病原学送检阳性标本9902份,分析病原菌分布及耐药情况.结果:导致腹腔感染的前五位病原体为大肠埃希菌(17.00%)、肺炎克雷伯菌(12.02%)、粪肠球菌(8.83%)、屎肠球菌(7.82%)、嗜麦芽寡养单胞菌(7.81%).大肠埃希菌对头孢他啶/阿维巴坦,肺炎克雷伯对环丙沙星,粪肠球菌对四环素、奎奴普丁/达福普汀,屎肠球菌对莫西沙星、青霉素G、阿莫西林、阿莫西林/克拉维酸、氨苄西林,嗜麦芽寡养单胞菌对美罗培南、亚胺培南耐药率超80%.结论:腹腔感染病人,最常见病原菌为大肠埃希菌;早期经验性治疗使用覆盖阴性杆菌及阳性球菌抗生素.大肠埃希菌感染避免使用头孢他啶/阿维巴坦,肺炎克雷伯菌感染避免使用环丙沙星,粪肠球菌感染避免使用奎奴普丁/达福普汀,屎肠球菌感染避免使用阿莫西林、青霉素G、莫西沙星、氨苄西林、阿莫西林/克拉维酸.
Abstract
Objective:To analyze the distribution and drug resistance of pathogenic bacteria in peritoneal infection in our hospital,and guide clinical rational drug use.Methods:From September 2018 to July 2024,9902 positive aetiological specimens related to abdominal infection were collected in our hospital to analyze the distribution and drug resistance of pathogenic bacteria.Results:The top five pathogens causing abdominal infection were Escherichia coli(17.00%),Klebsiella pneumoniae(12.02%),Enterococcus faecalis(8.83%),Enterococcus faecium(7.82%),and oligotrophomonas maltophil(7.81%).The resistance rate of Escherichia coli to ceftazidime/avibactam,Klebber pneumoniae to ciprofloxacin,Enterococcus faecalis to tetracycline,quinuptin/Dafoptene,Enterococcus faecium to moxifloxacin,penicillin G,amoxicillin,amoxicillin/clavulanate,ampicillin,and maltophilia to meropenem and imipenem exceeded 80%.Conclusion:In patients with abdominal infection,the most common pathogenic bacteria was Escherichia coli.Early empiric treatment uses antibiotics covering negative bacteria and positive bacteria.Avoid ceftazidime/avibactam for Escherichia coli infections,ciprofloxacin for Klebsiella pneumoniae infections,quinoptin/Dafoptin for Enterococcus faecalis infections,and amoxicillin,penicillin G,moxifloxacin,ampicillin,and amoxicillin/clavulanate for Enterococcus faecium infections.
维普
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