Prognosis of NF-κB and Acute Carbon Monoxide Poisoning in brain
Objective:To investigate the relationship between nuclear factor κB(NF-κB)and prognosis of brain injury caused by acute carbon monoxide poisoning.Methods:A total of 112 patients with acute carbon monoxide poisoning from December 2021 to January 2024 were selected as the study objects.Blood samples were collected from all patients at admission and 7 days after treatment,and serum NF-κB expression levels were detected by ELISA.At the same time,the patients underwent neurological examination and imaging evaluation,and were divided into good prognosis group and poor prognosis group according to the prognosis.The correlation of NF-κB level,age and time of poisoning between the two groups was analyzed by Pearson method.Results:Of the 112 patients,64 had good prognosis and 48 had poor prognosis.There was a statistically significant difference in NF-κB level between the two groups at admission(P<0.05)and after treatment(P<0.05).The corresponding NIHSS score was(5.2±2.8),the correlation coefficient was 0.687,and the P value was 0.003.In the poor prognosis group,the expression level of NF-κB was(18.9±3.5)ng/mL,the NIHSS score was(18.6±4.1),the correlation coefficient was 0.823,and the P value was 0.001.Conclusion:NF-κB level is significantly correlated with the prognosis of brain injury caused by acute carbon monoxide poisoning.Patients with higher serum NF-κB levels have an increased risk of poor outcomes.Detection of NF-κB level can provide a reference for prognosis assessment of patients with acute carbon monoxide poisoning.
万方数据
维普
