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泌尿结石患者术后尿路感染病原学及风险预测模型的构建

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目的:探讨泌尿结石患者术后尿路感染(UTI)病原学特征及危险因素,建立风险模型.方法:选取2020年1月-2024年8月广州市第一人民医院收治的156例泌尿结石术后患者为研究对象,依据术后是否出现UTI将其分为感染组(n=42)和未感染组(n=114),比较两组临床资料,筛选UTI的独立危险因素,构建UTI风险模型,并通过绘制工作特性(ROC)曲线来评价该模型的预测效果.结果:42例泌尿结石术后患者合并UTI,共检出54种致病菌,主要为大肠埃希菌、肺炎克雷伯菌、粪肠球菌、金黄色葡萄球菌及鲍氏不动杆菌.多变量Logistic回归方法显示,年龄≥60岁、糖尿病、结石直径、手术时间是术后并发UTI的独立危险因素(P<0.05.根据多因素Logistic回归分析筛选出的泌尿结石术后UTI的独立危险因素建立模型,同时利用ROC曲线对构建的模型进行内部验证,曲线下面积为0.850(95%CI:0.803-0.896)结果表明该模型具有较好的预测价值.结论:泌尿结石患者术后UTI以革兰阴性菌为主,且年龄≥60岁、糖尿病、结石直径、手术时间是术后并发UTI的独立危险因素;以上述因素为基础构建的风险模型对泌尿结石患者术后UTI的风险预测具有指导作用.
Establishment of Etiology and Risk Prediction Model for Postoperative Urinary Tract Infection in Patients with Urinary Calculi
Objective:To investigate the etiological characteristics and risk factors of postoperative urinary tract infection(UTI)in patients with urinary calculi,and establish a prediction model.Methods:156 patients with urinary calculi treated in Guangzhou First People's hospital from Jan 2020 to Aug 2024 were selected and divided into infected group(n=42)and uninfected group(n=114)according to whether UTI occurred after surgery.Multivariate logistic regression analysis was conducted to analyze the influencing factors of postoperative UTI in patients with urinary calculi.A UTI prediction model was established,and receiver operating characteristic ROC)curves were drawn to evaluate the effect prediction model.Results:In 42 patients with UTI after operation,54 kinds of pathogenic bacteria were detected,mainly Escherichia coli,Klebsiella pneumoniae,Enterococcus faecalis,Staphylococcus aureus and Acinetobacter baui.Multivariate Logistic regression method showed that age≥60 years old,diabetes mellitus,stone diameter and operation time were independent risk factors for postoperative UTI(P<0.05).The independent risk factors of UTI after urinary calculi operation were selected by multivariate Logistic regression analysis to construct a model,and the constructed model was internally verified by ROC curve.The area under the curve was 0.850,indicating that the model had good predictive value.Conclusion:Gram-negative bacteria are the main risk factors for postoperative UTI in patients with urinary calculi,and age≥60 years old,diabetes mellitus,stone diameter and operation time are independent risk factors for postoperative UTI.The prediction model based on the above factors can guide the risk prediction of postoperative UTI in patients with urinary calculi.

urinary calculiurinary tract infectionspredictive models

仝有成、冯小红、王淇

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广东省广州市第一人民医院泌尿外科(510180)

泌尿结石 尿路感染 病原学 危险因素 风险模型

2024

岭南急诊医学杂志
广东省医学会

岭南急诊医学杂志

影响因子:0.437
ISSN:1671-301X
年,卷(期):2024.29(6)