ST段抬高型心肌梗死患者血清转化生长因子11、补体C1q/肿瘤坏死因子相关蛋白5的表达及临床意义
Serum Expressions of Transforming Growth Factor 11 and Complement C1q/Tumor Necrosis Factor-Related Protein 5 and Their Clinical Significance in Patients with ST-Segment Elevation Myocardial Infarction
张国瑞 1张静 1杜超 1王立君 1刘莉莉 1秦利强1
作者信息
- 1. 石家庄市第三医院心内科,石家庄 050000
- 折叠
摘要
目的 探讨转化生长因子11(transforming growth factor 11,GDF11)、补体C1q/肿瘤坏死因子相关蛋白5(complement C1q/tumor necrosis factor-related protein 5,CTRP5)在ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者血清中的表达及诊断价值.方法 选取2019年3月到2021年2月石家庄市第三医院收治的60例STEMI患者为心肌梗死组,另选取同期健康体检者50名为对照组.检测两组受试者血清GDF11、CTRP5的表达水平.采用Pearson相关性分析对STEMI患者血清中GDF11和CTRP5表达水平及二者与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、血糖(blood glucose,GLU)、白细胞计数(white blood cell count,WBC)、中性粒细胞计数(neutrophil count,NEUT)、单核细胞计数(monocyte count,MONO)及超敏C反应蛋白(hypersensitive C reactive protein,hs-CRP)、高敏心肌肌钙蛋白T(high-sensitivity cardiac troponin T,hs-cTnT)、肌酸激酶同工酶(creatine kinase isoenzymes,CK-MB)浓度及预后不良事件的相关性进行分析.采用受试者工作特征曲线(receiver operating characteristic curve,ROC)分析血清中GDF11和CTRP5对STEMI患者的诊断价值.结果 心肌梗死组患者的血清GDF11(1.42±0.35 vs.0.99±0.18,t=7.860,P<0.05)和CTRP5(1.49±0.43 vs.1.01±0.22,t=7.148,P<0.05)表达水平高于对照组,差异有统计学意义.相关性分析结果显示,心肌梗死组血清GDF11和CTRP5表达水平呈正相关(r=0.550,P<0.05),GDF11和CTRP5表达水平与HDL-C呈负相关(r=-0.548,-0.592,P<0.05),与GLU(r=0.447,0.534,P<0.05)、WBC(r=0.653,0.502,P<0.05)、NEUT(r= 0.562,0.578,P<0.05)、MONO(r=0.439,0.423,P<0.05)、hs-CRP(r=0.513,0.542,P<0.05)、hs-cTnT(r=0.513,0.524,P<0.05)、CK-MB(r=0.630,0.417,P<0.05)及预后不良事件(r=0.557,0.529,P<0.05)呈正相关.GDF11和CTRP5联合诊断STEMI的ROC曲线下面积大于GDF11、CTRP5单独诊断(Z=2.424、2.507,P<0.05).结论 GDF11和CTRP5在STEMI患者血清中表达水平升高,两者联合对STEMI具有较高的诊断价值.
Abstract
Objectives To investigate the serum expression and diagnostic value of transforming growth factor 11(GDF11)and complement C1q/tumor necrosis factor-related protein 5(CTRP5)in patients with ST-segment elevation myocardial infarction(STEMI).Methods Sixty patients with STEMI admitted to Shijiazhuang Third Hospital from March 2019 to February 2021 were regarded as myocardial infarction(MI)group,another 50 healthy subjects were re-garded as control group.Serum expressions of GDF11 and CTRP5 were detected in the two groups.Pearson correlation was used to analyze the serum expressions of GDF11 and CTRP5 in patients with STEMI and their correlation with high-density lipoprotein cholesterol(HDL-C),blood glucose(GLU),white blood cell count(WBC),neutrophil count(NEUT),monocyte count(MONO),hypersensitive C reactive protein(hs-CRP),high-sensitivity cardiac troponin T(hs-cTnT),creatine kinase isoenzymes(CK-MB)and prognostic adverse events.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of serum expressions of GDF11 and CTRP5 in patients with STE-MI.Results The serum expressions of GDF11(1.42±0.35 vs.0.99±0.18,t=7.860,P<0.05)and CTRP5(1.49±0.43 vs.1.01±0.22,t=7.148,P<0.05)in MI group were higher than those in control group.Correlation analysis showed that the serum expressions of GDF11 and CTRP5 in MI group were positively correlated(r=0.550,P<0.05),and the serum expressions of GDF11 and CTRP5 were negatively correlated with HDL-C(r=-0.548,-0.592,P<0.05);they were pos-itively correlated with GLU(r=0.447,0.534,P<0.05),WBC(r=0.653,0.502,P<0.05),NEUT(r=0.562,0.578,P<0.05),MONO(r=0.439,0.423,P<0.05),hs-CRP(r=0.513,0.542,P<0.05),hs-cTnT(r=0.513,0.524,P<0.05),CK-MB(r=0.630,0.417,P<0.05)and prognostic adverse events(r=0.557,0.529,P<0.05).The area under ROC curve of combination of GDF11 and CTRP5 in diagnosis of STEMI was greater than that of GDF11 or CTRP5 alone in diagnosis(Z=2.424,2.507,P<0.05).Conclusions The serum expressions of GDF11 and CTRP5 in patients with STE-MI increased,and the combination of which has high value in diagnosis of STEMI.
关键词
心肌梗死/转化生长因子11/补体C1q/肿瘤坏死因子相关蛋白5/诊断Key words
myocardial infarction/transforming growth factor 11/complement c1q/tumor necrosis factor-related protein 5/diagnosis引用本文复制引用
基金项目
石家庄市科学技术研究与发展指导计划(171462253)
出版年
2024
NETL
NSTL
维普
万方数据