Diagnostic Value of Fetal Echocardiography Combined with Maternal Serum Concentrations of Secreted Frizzled-Related Protein 5 and Homocysteine in Fetuses with Congenital Heart Disease
Diagnostic Value of Fetal Echocardiography Combined with Maternal Serum Concentrations of Secreted Frizzled-Related Protein 5 and Homocysteine in Fetuses with Congenital Heart Disease
Objectives To analyze the diagnostic efficacy of fetal echocardiography combined with maternal serum concentrations of secreted frizzled-related protein 5(SFRP5)and homocysteine(Hcy)in fetuses with congenital heart disease.Methods From July 2018 to February 2022,2 756 pregnant women who underwent second-trimester prenatal examination in Shiyan Maternal and Child Health Hospital,were regarded as the research objects.According to pregnancy outcomes,they were grouped into congenital heart disease group(110 cases)and normal group(2 646 cases).Fetal echocardiography was performed during the second trimester,maternal serum concentration of SFRP5 was detected by enzyme-linked immunosorbent assay(ELISA).The serum concentration of Hcy was detected by an automatic biochemical analyzer.Pearson method was applied to analyze the correlations between maternal serum concentrations of SFRP5 and Hcy in CHD group.Taking pregnancy outcome as the"gold standard",the diagnostic efficacies of fetal echocardiography,maternal serum concentrations of SFRP5,Hcy and the combination of the three in fetuses with congenital heart disease was analyzed.Results The maternal serum concentration of SFRP5 in congenital heart disease group was obviously lower than that in normal group(P<0.05),and the serum concentration of Hcy was obviously higher than that in normal group(P<0.05).There was a negative correlation between the serum concentrations of SFRP5 and Hcy(r=-0.575,P<0.05).The sensitivity of fetal echocardiography,maternal serum concentrations of SFRP5 and Hcy in the diagnosis of fetuses with congenital heart disease was 63.64%,64.55%,and 65.45%,respectively,the specificity was 81.52%,81.07%,and 80.35%,and the accuracy was 80.81%,80.41%,and 79.75%,respectively.The sensitivity and accuracy of the combination of fetal echocardiography,maternal serum concentrations of SFRP5 and Hcy in diagnosing congenital heart disease in fetuses were 96.36%and 80.91%,respectively,which were higher than those of the three alone,and the sensi-tivity of the combined diagnosis of the three was obviously higher than that of the three alone(P<0.05).Conclusions Fetal echocardiography combined with maternal serum concentrations of SFRP5 and Hcy has high diagnostic value for fetuses with congenital heart disease,and the combined diagnosis of the three can improve the sensitivity.
关键词
先天性心脏病/胎儿超声心动图/分泌型卷曲相关蛋白5/同型半胱氨酸/诊断价值
Key words
congenital heart disease/fetal echocardiography/secreted frizzled-related protein 5/homocysteine/diag-nostic value
维普
万方数据