急性心肌梗死患者血清凝血酶敏感蛋白、C-X-C基序趋化因子配体9浓度及其临床意义
Serum Concentrations of Thrombin Sensitive Protein 1 and C-X-C Motif Che-mokine Ligand 9 in Patients with Acute Myocardial Infarction and Their Clini-cal Significance
朱网明 1崔春霞1
作者信息
- 1. 海安市人民医院急诊科,江苏海安 226600
- 折叠
摘要
目的 探究急性心肌梗死(acute myocardial infarction,AMI)患者血清凝血酶敏感蛋白1(thrombin sensitive protein 1,TSP1)、C-X-C基序趋化因子配体 9(C-X-C motif chemokine ligand 9,CXCL9)浓度及其临床意义.方法 选自2017年11月至2018年11月海安市人民医院收治的AMI患者125例为AMI组,正常健康体检者80名为对照组,采用实时荧光定量聚合酶链反应(real-time fluorescence quantitative polymerase chain reaction,qRT-PCR)法检测AMI组和对照组患者血清TSP1、CXCL9浓度;Pearson法分析TSP1与CXCL9之间的相关性;Kaplan-Meier生存曲线分析TSP1、CXCL9表达浓度与AMI患者术后3年生存情况的关系;Cox回归分析影响AMI患者术后3年预后不良的危险因素.结果 与对照组相比,AMI组患者血清TSP1、CXCL9浓度升高,差异有统计学意义(P>0.05).与轻度、中度病变组相比,重度病变组患者血清TSP1、CXCL9浓度升高,差异有统计学意义(P<0.05);与轻度病变组相比,中度病变组患者血清TSP1、CXCL9浓度升高,差异有统计学意义(P<0.05).AMI患者血清中TSP1与CXCL9浓度呈正相关(P<0.05).Kaplan-Meier生存曲线分析显示,TSP1高浓度组患者术后3年生存率低于低浓度组的生存率(P<0.05);CXCL9高浓度组患者术后3年生存率低于低浓度组的生存率(P<0.05).多因素COX回归分析显示,心肌肌钙蛋白I(cardiac troponin I,cTnI)、B型钠尿肽(B type natriuretic peptide,BNP)、TSP1和CXCL9高浓度是影响AMI患者术后3年预后不良的危险因素(P<0.05).结论 TSP1、CXCL9在AMI患者血清中呈高表达,与AMI患者预后有关,有望成为潜在的AMI预后评估生物标志物.
Abstract
Objectives To investigate the serum concentrations of thrombin sensitive protein 1(TSP1)and C-X-C motif chemokine ligand 9(CXCL9)in patients with acute myocardial infarction(AMI)and their clinical significance.Methods From November 2017 to November 2018,125 AMI patients admitted to Hai'an People's Hospital were taken as AMI group,and 80 normal healthy persons were regarded as control group.The serum concentrations of TSP1 and CXCL9 were detected by real-time fluorescence quantitative polymerase chain reaction(qRT-PCR)method;the correla-tion between TSP1 and CXCL9 was analyzed by Pearson method;Kaplan-Meier survival curve was performed to analyze the relationship between the serum concentrations of TSP1 and CXCL9 and the 3-year survival of patients with AMI;Cox regression was performed to analyze the risk factors for poor prognosis in patients with AMI at 3 years after surgery.Results Compared with control group,the serum concentrations of TSP1 and CXCL9 in AMI group were significantly increased(P>0.05).Compared with mild and moderate lesion groups,the serum concentrations of TSP1 and CXCL9 in severe lesion group were significantly increased(P<0.05);compared with mild lesion group,the serum concentrations of TSP1 and CXCL9 in moderate lesion group were significantly increased(P<0.05).The serum concentrations of TSP1 and CXCL9 in patients with AMI were positively correlated(P<0.05).Kaplan-Meier survival curve analysis showed that the 3-year survival rate of TSP1 high expression group was lower than that of low expression group(P<0.05);the 3-year survival rate of CXCL9 high expression group was lower than that of low expression group(P<0.05).Multivariate COX regression analysis showed that high expression of cardiac troponin I(cTnI),B type natriuretic peptide(BNP),TSP1 and CXCL9 were risk factors for poor prognosis in patients with AMI at 3 years after operation(P<0.05).Conclusions TSP1 and CXCL9 are highly expressed in the serum of AMI patients,which are related to the prognosis of AMI patients,and they are expected to be potential biomarkers for the prognosis assessment in patients with AMI.
关键词
心肌梗死/凝血酶敏感蛋白1/C-X-C基序趋化因子配体9/预后Key words
myocardial infarction/thrombospondin-1/C-X-C motif chemokine ligand 9/prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据