Objectives To explore the long-term efficacy of radiofrequency catheter ablation in patients with non-ischemic cardiomyopathy(NICM)complicated with ventricular tachycardia(VT),and analyze the factors that affect the efficacy of radiofrequency catheter ablation.Methods This study retrospectively analyzed the clinical data of patients admitted to Guangdong Provincial People's Hospital from January 2008 to December 2022 who were diagnosed with NICM-VT combined with VT and underwent catheter radiofrequency ablation.The clinical baseline data,electrophysiological data and follow-up results of the enrolled patients were collected,and the factors affecting the long-term curative effect were analyzed by univariate analysis and multi-factor analysis.Results A total of 106 patients(79 males and 27 females)with an average age of(45.3±15.9)years were included.After a follow-up of 33.2 months(median follow-up time),39 patients had VT relapse,thus the recurrence rate was 36.8%;8 patients died,and the mortality rate was 7.5%.Multi-variate regression analysis showed that age and VT type≥3 were independent risk factors for VT recurrence(HR=1.040,95%CI:1.011-1.067,P=0.006;HR=2.623,95%CI:1.250-5.479,P=0.011),but did not suggest that ablation pathway was an independent risk factor for VT recurrence.Heart failure readmission was an independent risk factor for all-cause death(HR=11.236,95%CI:1.728-73.074,P=0.011).Conclusions In NICM-VT patients undergoing ra-diofrequency catheter ablation,age and≥3 types of VT during operation are independent risk factors for VT recurrence,and heart failure readmission is an independent risk factor for all-cause death.