Objectives To investigate the value of peripheral blood hemoglobin(Hb),homocysteine(Hcy)and inter-leukin-17(IL-17)in predicting hypertension with atherosclerosis and their relationships with atherosclerosis.Methods Clinical data of 98 patients with hypertension complicated with arteriosclerosis admitted to Changsha Third Hospital from January 2018 to January 2020 was retrospectively analyzed,and the 98 patients were set as observation group.An-other 98 patients with hypertension admitted to our hospital during the same period were selected as study objects and set as control group.The basic data and concentrations of Hb,Hcy and IL-17 in peripheral blood of the two groups were compared,and the concentrations of Hb,Hcy and IL-17 in peripheral blood of patients with different degrees of ar-teriosclerosis in observation group were compared.The risk factors of hypertension combined with arteriosclerosis were ana-lyzed by multi-factor analysis,and the value of Hb,Hcy and IL-17 in predicting hypertension combined with arterioscle-rosis was analyzed by receiver operating characteristic curve(ROC).Spearman coefficient was used to analyze the corre-lations between the concentrations of Hb,Hcy and IL-17 and the degree of arteriosclerosis.Results The concentra-tions of Hcy and IL-17 in observation group were significantly higher than those in control group,the differences were statis-tically significant(P<0.05);the concentration of Hb in observation group was significantly lower than that in control group,the difference was statistically significant(P<0.05).Multiple Logistic regression analysis confirmed that Hb,Hcy and IL-17 were the risk factors of hypertension combined with arteriosclerosis(P<0.05).According to ROC analysis,Hb≤137.53 g/L,Hcy≥17.83 μmol/L and IL-17≥232.70 pg/mL were the best cut-off values for predicting hypertension complicated with atherosclerosis(P<0.05).The concentrations of Hcy and IL-17 in observation group was mild<moder-ate<severe,with statistical significance(P<0.05);the concentration of Hb was mild>moderate>severe,with sta-tistical significance(P<0.05).Correlation analysis showed that concentrations of Hcy and IL-17 were positively corre-lated with the degree of atherosclerosis(P<0.05),while concentration of Hb was negatively correlated with the degree of atherosclerosis(P<0.05).Conclusions The concentrations of Hb,Hcy and IL-17 in peripheral blood have good predic-tive values for hypertension complicated with atherosclerosis.The concentrations of Hcy and IL-17 are positively correlated with the degree of atherosclerosis,while the concentration of Hb is negatively correlated with the degree of atherosclerosis.
维普
万方数据