Clinical Efficacy of Vericiguat on The Treatment in Patients with Chronic Heart Failure and Its Influence on Quality of Life and Serum Concentration of Brain Natriuretic Peptide
Clinical Efficacy of Vericiguat on The Treatment in Patients with Chronic Heart Failure and Its Influence on Quality of Life and Serum Concentration of Brain Natriuretic Peptide
Objectives To explore the clinical efficacy of vericiquide on the treatment in patients with chronic heart failure and its effects on quality of life and serum concentration of brain natriuretic peptide(BNP).Methods By random number table method,126 patients with chronic heart failure admitted to Jiangsu Provincial People's Hospital from April 2021 to January 2023 were divided into two groups(63 cases each).Control group was given standardized chronic heart failure treatment,and observation group was treated with vericiguat tablets on the basis of control group.The clinical effi-cacy,quality of life,cardiac function index,adverse reactions,serum concentrations of BNP and intercellular adhesion molecule-1(ICAM-1)of the two groups were compared and analyzed.Results The total effective rate in observation group was 96.83%(61/63),which was significantly higher than that of control group which was 82.53%(52/63)(P<0.05).The cardiac index(CI)and left ventricular ejection fraction(LVEF)after treatment were higher than before treatment,and the indexes in observation group was significantly higher(P<0.05).Left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)after treatment in the two groups were lower than before treatment,and they in observation group were significantly lower(P<0.05).After treatment,the quality of life scores of both groups decreased,and the scoes in observation group were lower(P<0.05).After treatment,the serum concentrations of BNP and ICAM-1 in both groups decreased,and the serum concentrations of BNP and ICAM-1 in observation group were significantly lower(P<0.05).In the course of treatment,the vital signs were stable and no adverse reactions occurred in both groups.Conclusions Vericiguat has high efficacy and safety in the treatment of chronic heart failure patients,can improve their quality of life and cardiac function level,and reduce serum concentrations of BNP and ICAM-1,which is worthy of clinical promotion.
关键词
心力衰竭/维立西呱/生存质量/脑钠肽
Key words
heart failure/vericiguat/quality of life/brain natriuretic peptide
维普
万方数据