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中西药联用在老年糖尿病患者多重用药中的现状分析

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目的 分析中西药联用在老年糖尿病患者多重用药中的现状及相关性.方法 统计湖北文理学院附属襄阳市中心医院2023年11月内科出院的老年糖尿病患者的病历信息,分析中西药联用对老年糖尿病患者多重用药中不良结局的影响.结果 共纳入患者1 014例,多重用药771例(76.04%).老年糖尿病患者存在中西药联用462例(45.56%),其中活血化瘀类的中药占59.84%.83例(10.77%)老年糖尿病患者存在102次中西药不适当配伍,含甘草、丹参/三七、银杏叶等成分的中药与西药配伍时,易发生药物不良相互作用.老年糖尿病多重用药患者中,545例(70.69%)存在756次潜在不适当用药(Potentially inappropriate medication,PIM),胰岛素、氯吡格雷及艾司唑仑发生PIM次数较多.结论 老年糖尿病患者服用中药现象普遍.中西药联用增加了老年糖尿病患者多重用药率和潜在不适当用药发生率,易引起出血、低血糖、低钾血症等不良反应.中西药不适当配伍产生的不良药物相互作用容易被忽视,应采取适当措施提供警示作用.
Current situation analysis on combination of traditional Chinese medicine with West-ern medicine in polypharmacy of elderly patients with diabetes
Objective To analyze the current situation of combination use of Chinese medicine with Western medicine in polypharmacy of elderly patients with diabetes mellitus.Methods The medical records of elderly dia-betic patients discharged from the Internal Medicine Department of Xiangyang Central Hospital November 2023 were analyzed statistically,and the adverse impact of the combination of traditional Chinese medicine and Western medi-cines on polypharmacy for elderly diabetic patients was evaluated.Results A total of 1 014 patients were included in the study,including 771 patients(76.04%)with polypharmacy.Elderly patients with diabetes treated with combina-tion of traditional Chinese medicine with Western medicine were 462(45.56%),of which 59.84%were treated with traditional Chinese medicine for promoting blood circulation and removing blood stasis.Totally 83(10.77%)elderly patients with diabetes had 102 instances of inappropriate combination of traditional Chinese medicine with Western medicine.When Chinese medicine containing ingredients such as Licorice,Danshen/Sanqi,and Ginkgo biloba leaves were combined with Western medicine,adverse drug interactions were prone to occur.Among elderly diabetes patients with polypharmacy,there were 545 patients(70.69%)with 756 cases of potentially inappropriate medication(PIM),the most common drugs were insulin,clopidogrel,and eszopiclone.Conclusion It is common for elderly patients with diabetes to take traditional Chinese medicine.The combination of traditional Chinese medicine with Western medi-cine increases the rate of polypharmacy and PIM in elderly diabetic patients,resulting in bleeding,hypoglycemia,hypo-kalemia and other adverse reactions.The adverse drug interactions caused by inappropriate compatibility of Chinese medicine and Western medicine are easily overlooked.

Combination of traditional Chinese medicine with Western medicinePolypharmacyElderlyDiabe-tesDrug interactionPotentially inappropriate medication

慎聪琪、卞芳、杨颖

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武汉科技大学医学部医学院,湖北武汉 430081

湖北文理学院附属襄阳市中心医院药学部,湖北襄阳 441000

湖北文理学院附属襄阳市中心医院老年医学科,湖北襄阳 441000

中西药联用 多重用药 老年 糖尿病 药物相互作用 潜在不适当用药

2025

实用药物与临床
辽宁省药学会,中国医科大学附属盛京医院

实用药物与临床

影响因子:1.633
ISSN:1673-0070
年,卷(期):2025.28(1)