目的 分析舍曲林在儿童患者中致药物不良反应(Adverse drug reaction,ADR)的规律和特点,为临床安全用药提供参考.方法 检索知网、万方、维普、PubMed、Web of Science、Embase等数据库,检索时间为各数据库自建库起至2024年7月,收集已发表的舍曲林致儿童药物不良反应相关病例报道,并对纳入的文献进行统计分析.结果 共纳入文献35篇,纳入病例36例,其中男性15例(41.67％),女性21例(58.33％),共发生ADR40例次,大多ADR发生在用药0(给药当天)～30 d(30例,83.33％),主要累及神经系统(52.5％)、血液系统(10.0％)、泌尿系统(10.0％)、内分泌系统(10.0％)等,大多数ADR经停药和对症处理后能恢复正常,仍有少部分患儿干预后需长期康复治疗.结论 舍曲林可致儿童发生严重ADR,临床应加强该药的合理使用,用药期间密切监护和随访,以确保患儿临床用药安全.
Literature analysis of adverse drug reactions caused by sertraline in children
Objective To analyze the rule and characteristics of adverse drug reaction(ADR)caused by sertra-line in children,and to provide references for clinical safety of drug use.Methods Databases such as CNKI,Wan-fang,VIP,PubMed,Web of Science,Embase,etc.were searched.The search period was from the establishment of each database until July 2024.The published medical records related to adverse drug reactions caused by sertraline in children were collected,and statistical analysis was conducted on the included literatures.Results A total of 35 litera-tures were included,with 36 cases,including 15 males(41.67％)and 21 females(58.33％).A total of 40 ADR oc-curred,and most ADR(30 cases,83.33％)occurred within 30 days of medication,mainly affecting the nervous sys-tem(52.5％),blood system(10.0％),urinary system(10.0％),endocrine system(10.0％),etc.Most ADR could re-store to normality after discontinuation of medication and symptomatic treatment,while a small number of children still required long-term rehabilitation treatment after intervention.Conclusion Sertraline can cause serious ADR in children.Rational use of sertraline should be strengthened.Close monitoring and follow-up should be conducted to en-sure the safety of clinical use of sertraline in children.
万方数据
维普
