首页|替雷利珠单抗引发肾上腺皮质功能减退一例

替雷利珠单抗引发肾上腺皮质功能减退一例

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目的 分析替雷利珠单抗致肾上腺皮质功能减退的临床特点,为临床应对相关不良反应提供参考.方法 分析1例肺癌患者应用替雷利珠单抗治疗后出现肾上腺皮质功能减退的相关临床资料,对替雷利珠单抗与肾上腺皮质功能减退之间的关联性进行评价.结果 本例患者的肾上腺皮质功能减退与替雷利珠单抗很可能相关,应用糖皮质激素治疗后缓解.结论 替雷利珠单抗可能引起肾上腺皮质功能减退,且具有迟发性,应用时应加强监测.
A case of adrenal insufficiency caused by tislelizumab
Objective To analyze the clinical characteristics of adrenal insuffiiciency caused by tislelizumab,and provide a reference for clinical response to related adverse reactions.Methods The clinical data of adrenal insuf-ficiency in a lung cancer patient treated with tislelizumab was analyzed,and the correlation between tislelizumab and adrenal insuffiiciency was evaluated.Results Adrenal insufficiency of the patient was likely to be associated with tislelizumab and resolved after treatment with glucocorticoids.Conclusion Tislelizumab may cause adrenal insuffi-ciency,and monitoring should be intensified when tislelizumab is used.

TislelizumabAdrenal insufficiencyAdverse drug reactions

张俐婷、范理菊、邱学佳、安静

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河北医科大学,河北石家庄 050017

河北省人民医院药学部,河北石家庄 050051

河北省临床药学重点实验室,河北石家庄 050051

替雷利珠单抗 肾上腺皮质功能减退 药物不良反应

2025

实用药物与临床
辽宁省药学会,中国医科大学附属盛京医院

实用药物与临床

影响因子:1.633
ISSN:1673-0070
年,卷(期):2025.28(1)