首页|临床药师参与制订晚期结肠癌患者治疗方案的药学实践

临床药师参与制订晚期结肠癌患者治疗方案的药学实践

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因手足综合征不良反应,1例晚期结肠癌患者的治疗方案由口服卡培他滨调整为替吉奥,用药4d后,患者无法耐受替吉奥的恶心、呕吐不良反应,自行停用替吉奥.结合患者手足综合征改善,1个月后未再使用替吉奥,调整为减量的卡培他滨.临床药师持续监护患者病情变化.经过6个周期化疗,患者再次出现严重手足综合征,临床药师参与多学科团队综合治疗(MDT)团队,优化治疗方案,提供药学监护,促进患者临床安全用药.
Pharmaceutical practice of clinical pharmacists participating in the formulation of treatment plans for a patient with advanced colon cancer
The treatment plan of a patient with advanced colon cancer was adjusted from oral capecitabine to tegafur,gimeracil and oteracil potassium due to adverse reactions of hand-foot syndrome(HFS).After 4 days,due to the patient's inability to tolerate the adverse reactions of nausea and vomiting caused by tegafur,gimeracil and oteracil potassium,the drug was not used anymore.Considering the improvement of the patient's hand-foot syndrome,a re-duced dose of capecitabine was used after one month.Clinical pharmacists continuously monitored the changes in pa-tient's condition.After 6 cycles of chemotherapy,the patient experienced severe hand-foot syndrome again.Clinical pharmacists participated in MDT teams to optimize treatment plans,and provide pharmaceutical care to promote safe use of drugs in clinical practice.

Hand-foot syndromeTegafur,gimeracil and oteracil potassiumCapecitabinePharmaceutical care

何素梅、谢婧雯、朱洪宇、卢丽娜、张晓兰、江翊国

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南京大学医学院附属苏州医院药学部,江苏苏州 215153

南京大学医学院附属苏州医院放疗科,江苏苏州 215153

手足综合征 替吉奥 卡培他滨 药学监护

2025

实用药物与临床
辽宁省药学会,中国医科大学附属盛京医院

实用药物与临床

影响因子:1.633
ISSN:1673-0070
年,卷(期):2025.28(1)