Current status and recent advances in the use of bismuth quadruple therapy for heli-cobacter pylori eradication
Helicobacter pylori(Hp)is a common gastric mucosa pathogen,closely associated with various gastrointestinal diseases such as gastritis,peptic ulcers,and gastric cancer.Bismuth quadruple therapy(BQT),as a comprehensive treatment plan for Hp infection,consists of two antibiotics,a proton pump inhibitor(PPI)and bismuth.In recent years,it has demonstrated high efficacy and safety in the eradication treatment of Hp.This review aims to as-sess the current application of BQT in Hp eradication treatment and explore the impact of antibiotic resistance on the ef-ficacy of BQT as well as the latest research progress related to BQT.In summary,BQT,as an effective treatment regi-men for Hp eradication,faces the challenge of antibiotic resistance in current clinical practice.Future researches should focus on optimizing treatment,developing new antibiotics,and exploring personalized treatment strategies to further improve the eradication rate of Hp.
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