《圣济总录》芎附汤急性毒性实验
Acute Toxicity Test of Xiongfu Decoction
郭炜 1韩涛1
作者信息
- 1. 山东中医药大学,山东 济南 250355
- 折叠
摘要
目的:通过动物实验判断芎附汤的急性毒性,为临床用药提供安全依据.方法:给予小鼠灌胃芎附汤,通过预实验测定半数致死量(LD50),并据此测定最大耐受量(MTD).结果:急性毒性实验未能测出LD50,改测最大耐受量为240g/kg,相当于临床人用量的243倍.结论:芎附汤是安全有效的药物,可以在临床使用.
Abstract
Objective: Through animal experiments to determine the acute toxicity of Xiongfu Decoction, it provides a safe basis for clinical use. Method : Firstly judge the possibilities of determined half lethal dose( LD50) by the pre-experiment, and determine LD50 or the maximum tolerated dose ( MTD ). Result : Acute toxicity test can't measure the LD50. The largest dose ( MTD ) was 240g · kg-1, equivalent to clinical dose by 243 times. Conclusion, Xiongfu Decoction is safe and reliable and can be used in clinic.
关键词
芎附汤/急性毒性实验/最大耐受量/半数致死量Key words
Xiongfu Decoction/acute toxicity test/the largest dosage ( MTD )of the determination/LD50引用本文复制引用
基金项目
国家"重大新药创制"关键技术项目(2009ZX09502-015)
出版年
2012
国家科技期刊平台
NSTL
维普
万方数据