Effects of Cinnamon Polyphenols Improving HepG2 Cells Insulin Resistance
Objective: To study the influence of the cinnamon polyphenols on HepG2 cells insulin resistance. Methods:HepG2 cells were divided into control group, model group, metformin group (10 μg/mL)and cinnamon polyphenols groups with different doses (5,10,15μg/mL ). The effect of cinnamon polyphenols on viability of HepG2 cells was determined by 3- ( 4,5-dimethylthiazol-2-yl ) -2, 5-diphenylterazolium bromide ( MTT ) assay; insulin resistance cell model was induced by high concentrations of insulin, the hypoglycemic effect of cinnamon polyphenols in HepG2 cells was detected. Results : At the concentrations ( 1~ 15 μg/mL), the cinnamon polyphenols had no depressant effect on the cells activity. Cinnamon polyphenols could significantly promote extracellular glucose consumption in the HepG2 cells and the insulin resistance, moreover, with the increase of concentration, cinnamon polyphenols had more apparent hypoglycemic effect. Conclusion : Cinnamon polyphenols could significantly promote extracellular glucose consumption and the insulin resistance in the normal HepG2 cells, the low concentration can significantly enhance the cell sensitivity to insulin and improve the insulin resistance state.
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