辽宁中医药大学学报2025，Vol.27Issue(1) ：56-62.DOI:10.13194/j.issn.1673-842X.2025.01.010

基于层次分析-熵权法优化刺五加叶多组分超声提取工艺

Optimization of the Ultrasonic Extraction Process of Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)Multiple Components Based on Coupling Methodology of Analytic Hierarchy Process and Entropy Weight Method

彭艺璇 任冬雪 王和祥 郑明浩 刘秀波 薛岩 赵明星 郭盛磊
辽宁中医药大学学报2025，Vol.27Issue(1) ：56-62.DOI:10.13194/j.issn.1673-842X.2025.01.010
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  • 维普
  • 万方数据

基于层次分析-熵权法优化刺五加叶多组分超声提取工艺

Optimization of the Ultrasonic Extraction Process of Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)Multiple Components Based on Coupling Methodology of Analytic Hierarchy Process and Entropy Weight Method

彭艺璇 1任冬雪 1王和祥 1郑明浩 1刘秀波 2薛岩 3赵明星 3郭盛磊1
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作者信息

  • 1. 黑龙江中医药大学药学院,黑龙江 哈尔滨 150040
  • 2. 黑龙江中医药大学佳木斯学院,黑龙江 佳木斯 154000
  • 3. 哈尔滨市龙生北药生物工程股份有限公司,黑龙江 哈尔滨 150040
  • 折叠

摘要

目的 优化刺五加叶多组分超声提取工艺.方法 以HPLC法测定的刺五加叶中9种成分(原儿茶酸、L-苯丙氨酸、紫丁香苷、绿原酸、咖啡酸、异嗪皮啶、芦丁、金丝桃苷、槲皮素)作为评价指标,采用层次分析-熵权法对权重系数进行计算,结合响应面法(Box-Behnken),优化刺五加叶多组分超声提取工艺,并考察刺五加叶提取液的抗氧化活性.结果 Box-Behnken得出刺五加叶的最佳提取工艺为:超声功率580 W,超声时间23 min,料液比1∶25 g/mL,乙醇体积分数70％,超声温度35℃,在此条件下的综合评分为92.35,与模型预测值92.60差值甚小,RSD小于3％,且提取液具有较好的抗氧化作用.结论 刺五加叶多组分超声提取工艺稳定可行,且得到的刺五加叶提取液具有抗氧化性,为更好地开发利用刺五加叶资源提供了科学依据和技术支持.

Abstract

Objective To optimize the multicomponent ultrasonic extraction process of Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)leaves;ultrasonic extraction method.Methods Using HPLC method to conclude raw catechin acid,L-phenylalanine,syringin,chlorogenic acid,caffeic acid,pyridine,rutin,hypericum,quercetin 9 components as estimation index,the hierarchical analysis-entropy weight way to figure the weight coefficient,combined with the analytical hierarchy process-entropy weight method,optimate the multicomponent ultrasonic extraction course,and study the antioxidant activity of the extract.Results In the response surface,the best extraction process:ultrasonic power 580 W,ethanol fraction 70％,ultrasonic time 23 minutes,ultrasound 35℃,and 1∶25 g/mL.on this account,the comprehensive score was 92.35,less different from the model predicted value of 92.60,the RSD was less than 3％,and the extract has good antioxidant effect.Conclusion The multi-component ultrasonic extraction process of Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)is stable and feasible,and the obtained Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)extract has antioxidant properties,providing scientific basis and technical support for better development and utilization of Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)resources.

关键词

刺五加叶/超声提取法/熵权法/层次分析法/响应面法/抗氧化活性

Key words

Ciwujia(Acanthopanacis Senticosi Radix Et Rhizoma Seu Caulis)leaves/ultrasonic extraction method/entropy weight method/analytic hierarchy proces/response surface method/antioxidant activity

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出版年

2025
辽宁中医药大学学报
辽宁中医药大学

辽宁中医药大学学报

影响因子：0.775
ISSN：1673-842X
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