Mechanism of Oxidative Stress in Endometriosis and Research Progress of Tradition Chinese and Western Medicine Antioxidant Treatment
Endometriosis(EMs)is a common hormonal inflammatory disease with features similar to those of malignancy,including cell growth,invasion,distant metastasis,and recurrence,and the incidence of the disease is gradually increasing.Numerous studies have demonstrated that high levels of oxidative stress contribute to inflammation,angiogenesis,and cell proliferation,which correlate with the development of EMs and are involved in several physiological and pathological processes in EMs.Therefore,improving antioxidant capacity is an important entry point for the treatment of EMs.The authors reviewed the relevant studies at home and abroad in recent years,and analyzed the role of oxidative stress in the pathogenesis of iron overload in the pelvic environment,chronic inflammatory response,and angiogenesis,and summarized the mechanism of antioxidant treatment of EMs from the perspective of traditional Chinese medicine(TCM)monomers,compounds,and Western medicine,and found that both TCM and Western medical treatments can regulate the transcriptional expression of relevant factors,modulate inflammatory response,sex hormone expression levels,and reduce isoforms through multi-targets and multi-channels.It was found that both TCM and Western medical treatments could regulate the inflammatory response through multi-target and multi-pathway regulation of the transcriptional expression of related factors,the expression level of sex hormones and reduce the size of the ectopic foci,and enhance the antioxidant capacity in the body.In this paper,we would like to summarize the pathogenesis of oxidative stress in EMs and discuss the mechanism of trandition Chinese and Western medicine in regulating antioxidant therapy for EMs,with the aim of providing new perspectives and ideas for the use of trandition Chinese and Western medicines in the treatment of EMs.
oxidative stressendometriosisiron overloadangiogenesistranditional Chinese and Western medicine treatment
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维普
