Research Progress on Hepatotoxicity of Buguzhi(Psoraleae Fructus)and Its Mechanism of Compatibility and Attenuation
Buguzhi(Psoraleae Fructus)is the dried mature fruit of the leguminous plant of Psoralea corylifolia Linn.,which has the effect of tonifying the kidney and strengthening the Yang,fixing essence and shrinking urine,nourishing the Qi and calming the asthma,warming the spleen and stopping diarrhea,and eliminating the wind and removing the blemishes.However,improper application can cause certain adverse reactions,of which hepatotoxicity is one of the most significant toxic reactions.The chemical composition of Buguzhi(Psoraleae Fructus)is very complex,including psoralen,isopsoralen,and bakuchiol and other compounds,which are not only the active ingredients,but also the main cause of liver injury,and its toxicity mechanism is related to cholestasis,endoplasmic reticulum stress,oxidative stress,mitochondrial damage,induced hepatic lipoatrophy,and disruption of lipid metabolism homeostasis.Compounding to reduce toxicity is a commonly used method to reduce the toxicity of drugs in traditional Chinese medicine.It was found that the combination of Buguzhi(Psoraleae Fructus)with other herbs such as Wuweizi(Schisandrae Chinensis Fructus),Roudoukou(Myristicae Semen),Huangqi(Astragali Radix),Heshouwu(Polygoni Multiflori Radix),Chishao(Paeoniae Radix Rubra),Gancao(Glycyrrhizae Radix Et Rhizoma),Duzhong(Eucommiae Cortex)can effectively reduce hepatotoxicity through antioxidant,relieving endoplasmic reticulum stress,decreasing in vivo exposure to toxic components,inhibiting inflammatory response,and slowing down the production of toxic metabolites.The paper summarizes the latest research progress on the hepatotoxicity of Buguzhi(Psoraleae Fructus)and the mechanisms related to their toxicity reduction,with a view to providing a reference for the further development of Buguzhi(Psoraleae Fructus)and their safe use in clinical practice.
万方数据
维普
