Experimental Research Progress on the Regulation of Autophagy in Traditional Chinese Medicine for the Prevention and Treatment of Alzheimer's Disease
Alzheimer's disease(AD)is a progressive neurodegenerative disease with multiple pathogenic factors and complex pathological mechanisms,involving the disruption of multiple biological processes and molecular mechanisms.The treatment philosophy of traditional Chinese medicine emphasizes a holistic approach and individualized treatment,which can intervene in multiple pathological stages of AD and improve the quality of life of patients.Many studies have shown that autophagy plays an important role in the treatment of AD in traditional Chinese medicine.This article summarizes experimental research in the past five years and finds that various intervention methods in traditional Chinese medicine can regulate autophagy and its signaling pathways,thereby exerting therapeutic effects on AD.These interventions mainly include traditional Chinese medicine and its compounds and acupuncture and moxibustion treatment.Traditional Chinese medicine and its compound formulas,through their multi-component and multi-target characteristics,can intervene in multiple pathological stages of Alzheimer's disease.They can promote autophagy activity,eliminate abnormal protein accumulation,and inhibit excessive autophagy,preventing neuronal self damage.Acupuncture and moxibustion therapy can regulate the function of nervous system by stimulating acupoints,affect the expression of autophagy related genes and the activity of signal pathways,and then improve the pathological status of AD.This article focuses on the modern pathological mechanism of how traditional Chinese medicine regulates autophagy to prevent and treat Alzheimer's disease,aiming to provide new research directions and therapeutic targets for clinical improvement of Alzheimer's disease from the perspective of regulating autophagy.
Alzheimer's diseaseautophagytraditional Chinese medicineresearch progressacupuncture and moxibustion
万方数据
维普
