With the gradual deepening of scientific research,the rapid development of tumor immunotherapy brings more treatment opportunities to patients with advanced malignant tumors,and more and more patients benefit from it.Although immunotherapy has improved the overall survival of some tumor patients,its single-drug response rate is not high,and the high cost of immune drugs also greatly limits its clinical sustainable application.Therefore,how to maximize the efficacy of immunotherapy has gradually become a hot issue in the field of cancer research.The role of intestinal flora in immunotherapy has gradually attracted attention.Modern research has found that beneficial probiotics,such as Lactobacillus and Bifidobacterium,can improve the efficacy of immunotherapy.The spleen is the acquired foundation,the source of Qi and blood biochemistry.The physiological function of intestinal flora is similar to that of spleen in traditional Chinese medicine.Many studies have confirmed that TCM invigorating Qi and strengthening spleen method can regulate intestinal flora,increase probiotics,reduce harmful bacteria,and improve immune function.Therefore,this paper summarizes the research status of invigorating Qi and strengthening spleen method by regulating intestinal flora,improving intestinal microenvironment and improving the efficacy of tumor immunotherapy,in order to provide reference for clinical application.
关键词
益气健脾法/免疫治疗/肠道菌群/免疫检查点抑制剂/恶性肿瘤
Key words
invigorating Qi and strengthening spleen method/immunotberapy/gut microbiota/immune checkpoint inhibitor/malignant tumor
维普
万方数据