Research Progress on the Mechanism of Berberine on Hepatocellular Carcinoma Cells
Berberine,an isoquinoline quaternary ammonium alkaloid extracted from Huanglian(Coptidis Rhizome),exhibits anti-liver cancer properties by targeting multiple pathways.Its anti-hepatoma mechanism involves inhibition of cell proliferation,apoptosis induction,prevention of epithelial-mesenchymal transition,suppression of migration and invasion,promotion of autophagic cell death,cell cycle arrest,and inhibition of angiogenesis.This review summarizes recent literature on berberine's efficacy against hepatoma cells,highlighting challenges such as poor solubility and low bioavailability.Novel dosage forms are recommended to enhance berberine's therapeutic potential.Future research should focus on elucidating berberine's mechanisms and developing innovative anti-liver cancer therapies.
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