Mechanism and Related Research Progress of Buyang Huanwu Decoction(补阳还五汤)in Preventing and Treating Postoperative Angina Pectoris after Percutaneous Coronary Intervention
Buyang Huanwu Decoction(补阳还五汤)is a famous prescription recorded in Correction of Errors in Medical Classics that tonifies Qi and promotes blood circulation.It is commonly used in the clinical treatment of Qi deficiency and blood stasis syndrome.The syndrome differentiation of angina pectoris after percutaneous coronary intervention(PCI)surgery often belongs to Qi deficiency and blood stasis.This article reviews the mechanism and clinical research progress of using Buyang Huanwu Decoction to prevent and treat postoperative angina after PCI in recent years.In terms of combating inflammatory reactions,Buyang Huanwu Decoction can inhibit various signaling pathways such as NF-κB signaling pathway and MAPK signaling pathway,and reduce hs-CRP,IL-18,sICAM-1,TNF-α levels of various inflammatory factors to exert anti-inflammatory effects.In terms of antioxidant damage,Buyang Huanwu Decoction activates the Nrf2/ARE signaling pathway;Enhance SOD activity during reperfusion period,increase MDA concentration and other antioxidant stress damage pathways to counteract the damage caused by myocardial reperfusion.In terms of protecting blood vessels,Buyang Huanwu Decoction can increase VEGF levels,slow down the apoptosis process of EPCs,promote the repair of damaged blood vessels after PCI,and form new blood vessels.In terms of regulating blood lipids,Buyang Huanwu Decoction can improve blood lipid levels,reduce blood viscosity,and improve the prognosis of patients after PCI.The article reviews the above four aspects in order to provide reference and guidance for future research on the mechanism of action and clinical treatment of Buyang Huanwu Decoction in the prevention and treatment of post PCI angina.
Buyang Huanwu Decoction(补阳汤)post percutaneous coronary interventionangina pectorisreplenish Qi and activate bloodmechanism of actionresearch progress
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维普
