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经典名方温经汤研究进展及质量标志物预测分析

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经典名方温经汤收载于《妇人大全良方》,具有温经补虚、化瘀止痛之功效,为治疗妇人月经不调、血海虚寒、气血凝滞的常用方剂,该研究整理总结了近些年有关温经汤的现代研究成果,其药理研究表明温经汤具有改善供血、抗炎、镇痛等药理作用。临床主要用于痛经、月经不调、子宫内膜异位症等女性疾病。通过对其化学成分、药理作用以及现代临床应用的分析,并基于质量标志物(Q-Marker)"五原则",即质量传递与溯源、成分特有性、成分与药效关联、成分可测性及复方配伍环境对温经汤的Q-Marker进行预测分析,初步分析人参皂苷Rg1、Re、Rb1、阿魏酸、丹皮酚、芍药苷、芍药内酯苷、肉桂酸、藁本内酯、莪术醇、莪术二酮、甘草苷、甘草酸等成分与其药效相关,可作为温经汤的Q-Marker,以期为后续建立完整的温经汤质量评价体系提供参考依据。
Research Progress of Classic Recipe Wenjing Decoction(温经汤)and Prediction Analysis of Quality Marker
The classic prescription Wenjing Decoction(温经汤)was published in Women's Complete Prescription.It has the effect of warming menstruation and tonifying deficiency,removing blood stasis and relieving pain.It is a common prescription for treating women with irregular menstruation,cold deficiency of blood sea and stagnation of Qi and blood.Clinical mainly used for dysmenorrhea,irregular menstruation,endometriosis and other female diseases.Through the analysis of its chemical composition,pharmacological action and modern clinical application,and based on the"five principles"of quality marker(Q-Marker),namely,quality transmission and traceability,component specificity,component and drug effect correlation,component measuability and compound compatibility environment,Q-Marker of Wenjing Decoction was predicted and analyzed.Ginsenosides Rg1,Re,Rb1,ferulic acid,paeonol,paeonol,paeonolide,paeonolide,cinnamic acid,ligusticolide,curcumenol,curcumendione,glycyrrhizin and glycyrrhizic acid were related to their drug efficacy,which could be used as Q-Marker for Wenjing Decoction,in order to provide reference for the subsequent establishment of a complete quality evaluation system for Wenjing Decoction.

Wenjing Decoction(温经汤)classic prescriptionsresearch progressQ-Marker

李军鸽、王永春、邱智东、王彩虹、孟珈同、王振洲、唐秋竹

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长春中医药大学,吉林长春 130117

温经汤 经典名方 研究进展 质量标志物

2025

辽宁中医药大学学报
辽宁中医药大学

辽宁中医药大学学报

影响因子:0.775
ISSN:1673-842X
年,卷(期):2025.27(1)