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中医药调节肠道菌群治疗多囊卵巢综合征研究进展

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多囊卵巢综合征作为一种女性最常见的内分泌疾病,其伴有的胰岛素抵抗,高雄激素血症以及不孕等临床表现严重影响女性的心理及生活。但其病机尚不明确,近年来宏观基因组学等技术的发展,肠道菌群被发现通过改变肠道通透性、参与免疫炎症反应、代谢以及肠脑轴等多种途径参与多囊卵巢综合征的发生发展,因此可以通过调节肠道菌群来治疗多囊卵巢综合征。而中医药治疗多囊卵巢综合征有明显疗效,大量研究证实中医药可以通过调节肠道菌群结构,改善肠道屏障,降低炎症损伤,增强肠道黏膜免疫来治疗多囊卵巢综合征。本文总结了近年来研究发现的多囊卵巢综合征患者肠道菌群的改变,参与多囊卵巢综合征发病机制以及中药复方和中药单体通过调节肠道菌群治多囊卵巢综合征的研究,为防治多囊卵巢综合征以及中医药的使用提供参考。
Research Progress of Traditional Chinese Medicine in the Treatment of Polycystic Ovary Syndrome by Regulating Intestinal Flora
Polycystic ovary syndrome(PCOS)is one of the most common endocrine disease in women.Its clinical manifestations,such as insulin resistance,hyperandrogenism and infertility,seriously affect women's psychological and life.But its pathogenesis is not clear,in recent years,the development of macro-genomics and other technologies,it has been found that the gut microbiome can participate in the pathogengsis of PCOS by altering intestinal permeability,immune inflammatory response,metabolism,and gut-brain axis.Therefore,polycystic ovary syndrome can be treated by regulating the intestinal flora.However,traditional Chinese medicine(TCM)has obvious curative effect on PCOS.A large number of studies have proved that TCM can improve intestinal barrier and reduce inflammatory injury by regulating the structure of intestinal flora,treatment of polycystic ovary syndrome by enhancing intestinal mucosal immunity.This article summarizes the changes of intestinal microflora in patients with PCOS in recent years,to participate in the study on the pathogenesis of PCOS and the treatment of PCOS by modulating intestinal microflora with Chinese herbal compounds and monomers,so as to provide reference for the prevention and treatment of PCOS and the use of Chinese medicine.

polycystic ovary syndromeintestinal floratraditional Chinese medicine

李秋颖、周游、刘一、徐淑颖、陈莹、张阳、王丽娜

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辽宁中医药大学,辽宁沈阳 110847

辽宁中医药大学附属医院,辽宁沈阳 110032

多囊卵巢综合征 肠道菌群 中医药

2025

辽宁中医药大学学报
辽宁中医药大学

辽宁中医药大学学报

影响因子:0.775
ISSN:1673-842X
年,卷(期):2025.27(1)