Discussion of the Pathogenesis of Parkinson's Disease Neuroinflammation and the Progress of Chinese Medicine Intervention Based on the Theory of"Kidney Deficiency and Toxic Damage"
Neuroinflammation is an immune response,the main purpose of which is to protect the central nervous system(CNS)parenchyma and promote tissue repair,only acute short-term activation of immune cells is considered neuroprotective,whereas severe injury and sustained immune response imbalances the neurochemical processes of the CNS,transforming it into a chronic and excessive inflammatory response,leading to progressive neuronal death and ultimately causing the development of Parkinson's disease(PD).Therefore,neuroinflammation is closely related to the development of PD,so regulating the level of neuroinflammation is of great significance in the treatment of PD."Kidney deficiency and toxic damage"refers to the pathological process in which the deficiency of kidney Qi,blood,Yin and Yang triggers poor blood circulation and abnormal fluid metabolism,resulting in the accumulation of phlegm and blood stasis in the body,which ultimately becomes poisonous and destroys the cerebral complexes,with"kidney deficiency"as the main factor.The neuroinflammatory mechanism of PD is interlinked with"kidney deficiency and toxicity",and the deficiency of kidney Qi,blood,Yin and Yang is the key factor for the transformation of PD immune cells into chronic inflammation,while phlegm and stagnant blood stagnation is the direct factor for the neurological damage of PD.The combination of these two factors makes the activation of immune cells develop in the direction of unfavorable inflammatory reactions,which ultimately leads to the occurrence and continuous progression of PD.At present,a large number of studies have shown that traditional Chinese medicine(TCM)can effectively treat PD and has unique advantages.This paper summarizes and analyzes the literature at home and abroad in recent years to review the mechanism of PD neuroinflammation and the prevention and treatment of PD by TCM through the modulation of neuroinflammation,with the aim of providing a reference for the development of TCM for the prevention and treatment of PD as well as for the study of rational clinical use of medicines.
Parkinson's diseaseneuroinflammationtraditional Chinese medicinekidney deficiency and toxic damageresearch progress
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