目的 基于控糖效果及胰岛素抵抗变化情况探究化浊疏肝祛瘀法联合穴位贴敷在2型糖尿病前期(T2DM)患者中的应用价值。方法 选择张家口市中医院2021年5月-2023年5月收治的118例2型糖尿病前期患者。按随机数字表法分为对照组与观察组各59例，对照组给予生活方式干预，观察组给予生活方式干预+化浊疏肝祛瘀汤+穴位贴敷治疗。对比两组疗效、中医证候积分、控糖效果、胰岛素抵抗变化情况。结果 干预后，观察组的疗效等级及有效率均优于对照组(P＜0。05);两组各主次证候积分均较降低(P＜0。05)，且观察组的倦怠乏力、纳呆便溏、头身困重、脘腹胀满、口淡无味或黏腻的积分均低于对照组(P＜0。05);两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、血红蛋白(HbAlc)降低(P＜0。05)，且观察组均低于对照组(P＜0。05);两组胰岛素抵抗指数(HOMA-IR)均降低、胰岛β细胞功能指数(HOMA-β)均升高(P＜0。05)，且观察组的HOMA-IR低于对照组、HOMA-p高于对照组(P＜0。05)。干预期间，观察组患者未出现肝肾降低情况及不良反应。结论 化浊疏肝祛瘀汤联合中药贴敷治疗糖尿病前期疗效确切，可明显改善患者症状，降低血糖及胰岛素抵抗，改善胰岛β细胞功能，且安全性较好。
Application Value of Huazhuo Shugan Quyu Method Combined with Acupoint Application on Patients with Type 2 Prediabetes Based on Glucose Control Effect and Insulin Resistance Changes
Objective To explore the application value of Huazhuo Shugan Quyu method combined with acupoint application on patients with type 2 prediabetes based on glucose control effect and insulin resistance changes.Methods 118 patients with type 2 prediabetes admitted to Zhangjiakou hospital of traditional Chinese medicine were selected from May 2021 to May 2023 and were divided into control group and observation group by means of the random number table method,with 59 cases in each group.The control group was given lifestyle intervention,while the observation group was given lifestyle intervention+Huazhuo Shugan Quyu Decoction(化浊疏肝祛瘀汤)+acupoint application.The efficacy,TCM syndromes scores,glucose control effect and insulin resistance changes were compared between both groups.Results After intervention,the efficacy grading and effective rate in observation group were better than those in control group(P＜0.05).The scores of primary and secondary syndromes were reduced in the two groups(P＜0.05),and the scores of fatigue and lack of strength,poor appetite and loose stool,heaviness in head and body,abdominal fullness and distention,pale tasteless or sticky mouth in observation group were lower than those in control group(P＜0.05).The levels of fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG)and hemoglobin(HbAlc)in the two groups were decreased(P＜0.05),and the levels in observation group were lower(P＜0.05).The homeostasis model assessment of insulin resistance(HOMA-IR)in both groups was declined while the homeostasis model assessment of islet β cell function index(HOMA-β)was risen(P＜0.05).The HOMA-IR in observation group was lower while the HOMA-β was higher compared to control group(P＜0.05).During intervention,there was no liver-kidney reduction and adverse reaction in observation group.Conclusion Huazhuo Shugan Quyu Decoction combined with traditional Chinese medicine application has an exact efficacy in the treatment of prediabetes.It can significantly improve the TCM symptoms,reduce the blood glucose and insulin resistance,and improve the islet β cell function,and has good safety.
type 2 prediabetesglucose control effectinsulin resistanceHuazhuo Shugan Quyu methodacupoint application
万方数据
维普
