Role of Autophagy in Myocardial Ischemia-Reperfusion Injury and Research Progress on Traditional Chinese Medicine Intervention
Acute myocardial infarction(AMI)is a common cardiovascular crisis in clinical practice.Early reperfusion is the most effective treatment for AMI,but the restoration of blood supply may cause myocardial ischemia-reperfusion injury(MIRI),reducing clinical benefits.Autophagy is a protective mechanism in which cells utilize lysosomes to degrade damaged organelles,abnormal proteins,and other substances,providing energy to maintain homeostasis in the internal environment.In recent years,a large number of studies have shown that traditional Chinese medicine can effectively regulate cellular autophagy levels through multiple pathways and targets,alleviate oxidative stress and endothelial damage,reduce myocardial cell apoptosis,and thereby improve MIRI.This article reviews the relationship between autophagy and its related pathways with MIRI based on the occurrence and regulatory mechanisms of autophagy;At the same time,a systematic classification and summary of single traditional Chinese medicine,its active ingredients,and traditional Chinese medicine formulas targeting cell autophagy to treat MIRI in recent years is conducted,aiming to provide new ideas and theoretical support for the clinical treatment of MIRI with traditional Chinese medicine.
autophagymyocardial ischemia-reperfusion injurymechanism of actiontraditional Chinese medicine
万方数据
维普
